You can take your existing HTML5/CSS3/JS skills to create first class apps in Windows 8. Not BROWSER based apps. Windows 8 apps. You can package them up, and sell them in the Windows Store, and make real money with them. Cool!
I’ve had the privilege over the past month to present what I have learned about Windows 8 HTML5/JS apps to the San Diego HTML5, and the San Diego JS meetups. If you happened to miss either of those, or just want to see why I am excited about it in general you can: